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Company
SK nabs approval for cilostazol-ginko combination SR drug
by
Lee, Seok-Jun
Mar 29, 2020 11:19pm
On Mar. 25, SK Chemicals has announced the Korean health authority has approved sustained release tablet version of antiplatelet drug Renexin. Renexin is a combination drug consisting of antiplatelet agent cilostazol (200 mg) and ginko biloba extract (160 mg). The combination drug, with cilostazol and ginko biloba extract inhibiting platelet aggregation and blood clot formation, has been confirmed to be effective on improving chronic total occlusions in peripheral arteries-induced ischemic events and preventing recurrent stroke. The Korean-made drug is the world’s first drug to combine the two agents. Moreover, Renexin sustained-release (SR) tablet has significantly reduced the number of adverse events like headache in cilostazol. A Phase III clinical trial conducted in 18 Korean clinical institutes including Severance Hospital has found Renexin SR tablet reduced the prevalence of adverse events by 43 percent than the existing tablet. The SR tablet has also enhanced patients’ drug adherence and convenience with once-daily administration.
Company
Lipitor and Vytorin to be priced lower than generic?
by
Eo, Yun-Ho
Mar 29, 2020 11:18pm
An odd phenomenon of the original’s pricing dipping down to 85 percent of the lowest generic pricing may actually happen in Korea. The stepped drug pricing system coming in effect from July prices same-substance drugs under differentiated pricing depending on drugs meeting two qualifying standards. But from 21st same-substance drug, the pricing is fixed at 85 percent of the lower price between the lowest price of the drugs or 38.69 percent of the original’s price. However, a controversy sparked when the Ministry of Health and Welfare (MOHW) explained the stepped drug pricing system would be applied on ownership-transferred drugs. Pharmaceutical companies splitting recently like Pfizer and MSD are currently in process of transferring multiple original products to their spin-offs. And these companies may get impacted critically by the government’s interpretation. ◆"Transferred original? To the back of the line!” The controversy over the reduced original pricing started from the ‘Pharmaceutical Decision and Adjustment Standards’ revised in last February. The Section Ma (마) of the revised drug pricing notice stipulates a drug applying for pricing decision, listed previously but removed, would be priced at its latest maximum price, if it is either a transferred drug by inheritance, business transfer or merge as stated by the Pharmaceutical Affairs Act Paragraph 1 of Article 89, or a transferred drug by importer’s inheritance, business transfer or merge as stated by the Pharmaceutical Affairs Act Paragraph 2 of Article 42. In other words, the manufacturer (usually a Korean company) or the importer (multinational company) transferring a drug with a business license would not be subject to pricing reduction. Nevertheless, the Section Ba (바) of the notice stipulates a drug applying for pricing decision, listed previously but removed, would be priced at a lower price between its latest maximum price or newly calculated price, if it is a transferred drug by the manufacturer’s business transfer as stated by the Pharmaceutical Affairs Act Paragraph 2 of Article 89. This could mean the drug reapplying for pricing could face pricing reduction depending on the number of listed generics and standard qualification stated by the drug pricing notice. For example, the first-in-class pharmaceutical reimbursement on Lipitor (atorvastatin) is removed in the process of Upjohn splitting off from Pfizer and taking over the drug. But Lipitor’s price would fall at 85 percent of same-substance drugs as it would be treated as a generic when reapplying for the listing with more than 20 generic already listed. MOHW official commented, “The Pharmaceutical Decision and Adjustment Standards do not distinguish original or generic, but it manages listing of ‘drugs.’ We see no reason for us to exempt first-in-class drug (usually an original) from the newly revised pricing calculation standards.” ◆"Inconsistent with the policy’s objective, exempt the original from pricing reduction” Basically, the industry is a turmoil. Some of them are considering on taking legal actions to protect their originals getting a price lower than generics. Nevertheless, there is a chance for pharmaceutical companies to protect the original’s pricing even with imminent business and product transfer issues. MOHW has decided to apply the existing standards on products applying for listed pricing by May 2020, unless the products have special condition or need to submit additional data. Therefore, if Upjohn and Organon splitting off from Pfizer and MSD, respectively, were to process the transfer fast enough, they would be able to avoid the pricing reduction. Upjohn would take over Lipitor, Norvasc and Celebrex, whereas Organon is planning to take over Vytorin, Singulair and Zetia. But the window is opened to those two companies only. Multinational companies splitting off-patent drug specializing division in the future would take a heavy blow. In fact, many of global companies are either planning to or considering on a spin-off. Increasing number of Korean companies is also shooting for transferring originals. Because of the situation, Pfizer and MSD may request for rapid approval from their respective headquarters to finalize the transfer earlier. The pharmaceutical industry is infuriated at the Korean government. Considering the generic pricing system revision started from the safety issue of valsartan, the companies cannot accept the Pharmaceutical Decision and Adjustment Standards working against the original and reducing its price. Korean Research-based Pharmaceutical Industry Association (KRPIA) insider noted, “Although the generic pricing calculation has been modified, the contradicting factor in the existing regulation has not been touched up and created a loophole. The association has delivered the industry’s opinion, but we did not get the answer we wanted. The government would have to promptly set down correct interpretation of the regulation coinciding with the original objective of the revision and prevent any confusion in the market.” Regarding the issue, Attorney Lee Hyeong Gun and Song Hyun Ah at Lee & Ko commented, “The new generic pricing system affecting the original’s price when transferring seems to contradict the initial objective of the policy. Not only should the government thoroughly review the interpretation from legalistic point of view, but also it should take into account the possible impact on the original and patient’s options.”
Company
Novartis vs. Hanmi: Galvus generic to ignite legal dispute
by
Eo, Yun-Ho
Mar 26, 2020 06:12am
A conflict between Novartis and Hanmi Pharmaceutical is expected to deepen over the generic of the DDP-4 inhibitor Galvus. Novartis Korea is apparently preparing legal actions against Korean pharmaceutical companies attempting to evade patent infringement on Galvus (vildagliptin) by excluding one indication. The legal dispute over the patent would begin from next month as the reimbursement listing on Hanmi Pharmaceutical’s generic ‘Vildagle’ has been decided recently. Hanmi Pharmaceutical won an approval in January on four of indications of the original Galvus, except for the indication to treat a patient unable to control blood sugar level sufficiently with metformin monotherapy. The patent on the last indication is to expire in August 2021. Hanmi Pharmaceutical has requested negative confirmation of scope on the rest of the patents in last December to the Intellectual Property Trial and Appeal Board. The confirmation is still in process. Within the industry, the patent evading strategy has been used previously. Chong Kun Dang has launched a generic Dutesmol before the extended patent term of the original benign prostate hyperplasia and hair loss treatment Avodart (dutasteride) by GSK was expired. But according to Novartis, Galvus’ case is different from the precedent. Unlike Avodart with two contrasting indications of treating benign prostate hyperplasia and hair loss, all indications of Galvus are commonly treating type 2 diabetes. So evading infringement of extended patent term by dropping one indication would be unfeasible. Moreover, it would be impossible to confirm an off-label prescription of the generic for the patented indication as the Korean medical field only gives one prescription code on each disease. And Novartis has warned of forthcoming legal action against the Korean company. Novartis official stated, “The company sees this matter seriously and if the reimbursed Vildagle is to push on with the launch schedule before the patent expires, the company would take all possible legal actions including sales ban. Patent and intellectual property is the driving force of new drug development and pharmaceutical industry’s future advancement.” Regarding the issue, Hanmi Pharmaceutical official stated, “The official release date for Vildagle has not been set due to the COVID-19 outbreak. But the company would do everything to improve patient’s access to treatment and to relieve patients from financial burden by providing high quality generic to them.”
Company
FDA approves Phase III Actemra COVID-19 trial
by
An, Kyung-Jin
Mar 26, 2020 06:11am
Actemra product image A late-phase clinical trial in patients with severe case of the 2019 novel coronavirus (COVID-19) would be conducted with Actemra, solely distributed by JW Pharmaceutical in Korea. Roche Group’s Genentech has announced on Mar. 23 the U.S. Food and Drug Administration (FDA) has approved Actemra’s (tocilizumab) Phase III clinical trial in adult patients hospitalized with severe case of COVID-19 to test the medication’s treatment effect and safety profile. The news was out three days after the company informed Actemra is in discussion with FDA about a clinical trial to confirm its effect on COVID-19. Genentech is co-conducting the study with Biomedical Advanced Research and Development Authority (BARDA), a part of the U.S. Department of Health and Human Service (HHS) Office of the Assistant Secretary for Preparedness and Response. The primary and secondary endpoints are clinical status of a patient and mortality rate, and necessity of mechanical ventilator and ICU. Prior to the U.S. health authority’s approval, Actemra’s clinical trials in COVID-19 patient have been initiated globally to test effect and safety. But the study distinguishes itself from the previous studies with intricately designed protocol. Genentech stressed, “Actemra has not been indicated to treat patients with COVID-19, and its medical evidence on benefit to COVID-19 treatment has been limited.” Following the U.S. HHS’ order, the company plans to provide 10,000 vials of Actemra to the U.S. government. Alexander Hardy, the CEO of Genentech stated, “We thank the FDA for rapidly expediting the approval of this clinical trial to evaluate Actemra in critically ill patients suffering from COVID-19,” and “the company has decided to conduct this clinical trial in partnership with BARDA and to provide Actemra to support the national stockpile, through the efforts of Secretary Azar and HHS” Actemra is a humanized interleukin-6 (IL-6) receptor antagonist. The subcutaneous injection is widely used to treat rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis and cytokine release syndrome (CRS). In 2009, JW Pharmaceutical has signed a deal with Chugai Pharmaceutical under the Roche Group over Actemra for the co-development and exclusive sales in Korean market. The medication was released to the Korean market from 2013, after completing a Phase III study. In July 2014, Actemra SC injection with improved patient adherence was released in the Korean market.
Company
Celltrion, clinical trial in COVID-19 in July
by
Lee, Seok-Jun
Mar 26, 2020 06:10am
Chairman Jeong-jin Seo of Celltrion said on the 23rd, "This July, human clinical trials will be started for the development of COVID-19 treatments". He added, "It is possible to develop a therapeutic antibody for 1 million people per month after human administration". Chairman Seo shared this business plan through an online press conference held on the same day. According to the company, Celltrion is developing antibody treatments from February to receive COVID-19 confirmed patient's blood. Currently, 300 candidates have been obtained. Antibodies with excellent virus neutralization ability will be selected by April. It is administered to patients as early as mid-July. Celltrion will begin production of cell lines for mass production of antibodies from May, and production of clinical substances to be administered to the human body will be completed by mid-July or end of July. After the human administration has started, it will develop a therapeutic antibody for 1 million people per month. Antibody means an immune protein that binds to an antigen and interferes with the action of the antigen or removes the antigen. Overseas, Genentech and Eli Lilly are developing COVID-19 antibody treatments. The rate of antibody therapeutic development was the fastest. "COVID-19 neutralizing antibody therapeutics are being developed by five companies, including Korea Celltrion, two global large pharmaceutical companies, and two overseas biotechs", said Seo. He added that "Celltrion can be competitive in future developments due to its mass production capacity. In case of emergency, it has also planned to prepare for supply by using CMO partners". Celltrion also undertakes 'super antibody' screening to neutralize various coronaviruses (mutations, etc.). "In March, we will be screening for super antibody screening that neutralizes the COVID-19, as well as the SARS and even the common cold-causing corona virus. We will collect more blood samples and go ahead in speed", he said. It accelerates the development of the COVID-19 diagnostic kit prototype. The product that Celltrion is developing is a method to detect the S protein that is only present in COVID-19. It is different from the existing rapid diagnosis kit that detects the N protein commonly held by various types of corona viruses. "The Celltrion kit is expected to show performance close to RT-PCR, a standard diagnostic method for COVID-19 positive. 15-20 minutes is enough for test results, so it has the advantage of being able to check the test results on the spot". It is planned to apply for CE certification for export to Europe by completing the production of prototypes in late April and completing clinical trials by the end of May through collaboration with specialized companies.
Company
Balloon effect from impurity measures?
by
Chon, Seung-Hyun
Mar 25, 2020 06:03am
Recently, the number of new anti-ulcer drugs that enter the market is rapidly increasing. As the alternative drug market expanded after the Ranitidine’s withdrawal due to excessive detection of impurities in September last year, pharmaceuticals are also actively targeting the generic market. In addition to H2 receptor antagonists such as Famotidine and Laputidine, similar generic products such as Esomeprazole and Artemisia Princeps have also increased significantly. It is pointed out that the generic turmoil in the similar drug market is intensifying due to the balloon effect following the government's strong follow-up of impurities. According to the MOHW's revised notice on a partial revision of Criteria for pharmaceutical reimbursed list & reimbursed upper limit table, from April 1, 9 generic products of “Famotidine 20mg” will be listed on the pharmaceutical reimbursed list. Mirae Pharm, TDS Pharm, Theragen Etex, CMG Pharma, PMG Pharm, SCD Pharm, Daehan New Pharm, and Daewoong Bio sell Famotidine product. Kukje pharm, Arlico, Newgen Pharm, Korea Prime Pharm, Medix Pharm, Eden Pharma, Youngil pharm, Generic products with 'Laputinine', which were approved by eight companies including Kukje pharm, Arlico, Newgen Pharm, Korea Prime Pharm, Medix Pharm, Eden Pharma, Youngil pharm, were also newly added to the list. Famotidine and Laputidine are H2 receptor antagonist drugs and are used for gastric ulcer and duodenal ulcer. It is analyzed that drug companies are actively entering the alternative drug market since last year's banned sales of Ranitidine. The MFDS banned the sale of all products of 'Ranitidine' in late September last year. The market was virtually decided to exit due to the excess detection of the carcinogen N-nitrosodimethylamine (NDMA). September 2019 and April 2020 Famotidine 20mg (left) and Laputidine 10mg (right) Number of health insurance benefits registered (Unit: number, Data: the HIRAAccording to the HIRA, on September 1, last year, a total of 35 other companies were listed for Famotidine 20mg before the ban on the sale of Ranitidine was imposed. However, Famotidine 20mg, listed on April 1, increased 56 companies by 60%. In the case of Laputidine 10mg, the number of products on the reimbursed list increased 11 products from 29 in September last year to 40 in April. The surge in prescriptions of similar drugs after the ban on the sale of Ranitidine drugs is also analyzed as a factor that has pushed the market for pharmaceutical companies. According to UBIST, a pharmaceutical research institute, in December of last year, Outpatient prescriptions for five components, except Ranitidine, of H2 receptor antagonists such as Famotidine, Laputidine, Nizatidine, Cimetidine, and Roxatidine, were ₩10 billion. The prescription size soared 69.5% from August before the occurrence of impurities. The growth of Famotidine and Laputidine was steep. In December of last year, the prescription scale of the single component of Famotidine was ₩3.1 billion, more than three times higher than in August. The size of prescription for Famotidine last year was ₩17.5 billion, an increase of 38.0% compared to the previous year. In December last year, the amount of outpatient prescription for Lafutidine increased by 131.8% from August to ₩3 billion. As the prescription size of Famotidine and Laputidine expanded due to the reflex profit from the withdrawal of Ranitidine, pharmaceutical companies’ market activity was also active. Trends in monthly outpatient prescriptions by component of major H2 receptor antagonists (Unit: ₩1 million, Source: UBIST) Other drugs with similar uses to Ranitidine have also seen a significant increase in the number of generics. In the case of Esomeprazole 20mg (generic for Nexium) increased 16 from 108 to 124 on the benefit list in September. Esomeprazole is a proton pump inhibitor (PPI) -based drug and is most often used as an anti-ulcer agent. Esomeprazole also enjoyed the Ranitidine reflex benefit. Esomeprazole's prescription amount last year was ₩189.3 billion, up 17.1% from the previous year. Esomeprazole's prescription amount increased 20.6% from ₩15.1 billion in September last year to ₩18.2 billion in one month. In December of last year, it exceeded ₩20 billion. September 2019 and April 2020 Artemisia Princeps 90mg Health Insurance Benefits Registered (Unit: pcs, Source: the HIRA)The number of generics participating in the gastritis treatment Stillen market is also on the rise. Stillen is a gastritis treatment with 'Artemisia Princeps' as an active ingredient. Last year, the prescription size of Artemisia Princeps increased by 17.4% from the previous year to ₩87.5 billion. In September of last year, 15 Artemisia Princeps 90mg products were listed, which rose 73% to 26 in 7 months. The industry also complains that the government has been pushing the generics market for alternative medicines as a result of strong measures against impurity medicines. All products of Ranitidine have been discontinued in Korea, while pharmaceutical manufacturers have recovered their products by lot number in the US and Europe. The domestic market containing Ranitidine is about ₩200 billion per year. It is a reality that pharmaceutical companies that have suffered losses due to the sale of Ranitidine have a strategy to make up for other products. An industry insider said, “Excluding all products that have not been found to be harmful to the human body, considerable losses were inevitable and forced to compete in similar markets to make up for the losses”. The US Food and Drug Administration (FDA) issued a statement in November last year that "the hazards of NDMA detected in Ranitidine are comparable to those exposed when eating roasted or smoked meat". An official from a pharmaceutical company criticized, "The ban on the sale of all Ranitidine products in Korea also caused an excessive number of generics".
Company
Jina Lee at Bayer stepped up as CEO of Thai Corporation
by
Eo, Yun-Ho
Mar 24, 2020 05:20am
이진아 총괄Jina Lee, Health BU Head at Bayer, will be represented as the CEO of Thai corporation. Bayer Korea recently announced in its internal announcement that Jina Lee will be appointed as the CDH (Country Division Head) of the Thai Pharmaceutical Division. However, due to the aftermath of COVID-19, the exact departure schedule and the like have not been confirmed. Jina Lee, graduated from the Department of Pharmacy at Duksung Women's University, joined Merck Sereno in 2006 after joining Roche Korea in 1994 and joined Bayer in 2013 as Heart Health BU Head at Bayer. In 2018, she dispatched to Germany's head office marketing department, gained her experience, and returned to a Korean corporation in February last year. From October of last year, she was also a temporary representative for the pharmaceutical business division of a Korean corporation because former Ingrid Drexel was announced as a Turkish corporation. The Korean subsidiary later appointed the new CEO Freda Ta-Ling Lin in December of last year. Meanwhile, Bayer is divided into subsidiaries in the fields of medicine, chemical, and animal medicine such as healthcare, crop science, and material science. After joining Bayer, Jina Lee is said to be leading the cardiovascular business unit, and it is considered to be the leader of the growth of Xarelto (Rivaroxaban).
Company
Multinational Pharmaceuticals, COVID-19 Relief Goods
by
Eo, Yun-Ho
Mar 24, 2020 05:19am
Multinational pharmaceutical companies make donations to overcome COVID-19 crisis. According to the related industry, Korean corporations from multinational pharmaceutical companies such as Novartis, Mundipharma, Bayer, and Ferring, including the Korean Research-based Pharma Industry Association (KRPIA), have supported donations and relief supplies this month (March). Novartis recently donated 30,000 masks to the vulnerable. For the vulnerable people who are having difficulties in supply and demand, the company has delivered masks supported by the global headquarters to the KOREA PHS. The KOREA PHS is sponsoring educational and social welfare organizations approved by the MOEL, and are carrying out various sponsorship projects for the health and safety of the vulnerable to overcome this situation. On the 18th, Mundipharma donated a sanitary product kit to overcome COVID-19 crisis to the Seoul branch of the KACCC. Hygiene kits have been prepared to help personal hygiene management, such as washing hands of children and adolescents, in a situation where it is difficult to secure a quantity due to the recent increase in demand for hygiene products. the KACCC is a non-profit organization that provides integrated education and social welfare services to help children and adolescents in need of social care throughout the country enjoy a safe and happy life. Hygiene products will be delivered to each child center in the Seoul area and will be provided to children in need. Pharmaceutical companiesIn the case of Bayer, opinions were collected for each division. The company's contrast agent’s business division supported 280 contrast agents worth ₩13 million for chest coronary augmentation in severe COVID-19 infected patients through the Korean Open Doctors Society composed of medical workers. In addition, Bayer Healthcare recently provided 500 Redoxon vitamins to the Wolseong Social Welfare Center to support overcoming COVID-19 crisis in the Daegu region, which is struggling with the massive spread of COVID-19. Ferring Pharmaceuticals purchased 2,000 hand sanitizers and 200 protective clothing as donations from employees who voluntarily raised them, and donated them to the Daegu Metropolitan City Office's Disaster Safety Response Headquarters on the 5th. This donation started with the suggestion of one employee, and the purpose was to help the Daegu and Gyeongbuk areas, which suffered the most from the COVID-19 crisis. The KRPIA, a representative organization of multinational pharmaceutical companies, decided to donate ₩100 million to the Korean Red Cross so that they could be used at the COVID-19 quarantine site. Individual donations of pharmaceutical's employees are also conducted. If employees participate in a small fundraising, the KRPIA will add donations to the matching fund. The donations are sent to the Senior Citizens Support Center for Living Alone, which is affiliated with the Ministry of Health and Welfare, and are used to purchase emergency kits for food and beverages and supplies for health aids to the elderly living alone in vulnerable groups, including Daegu and Gyeongbuk. Avi BenShoshan, President of the KRPIA said, "Global pharmaceutical companies, as part of the Korean society, will strive to contribute to the efforts of various local communities to overcome COVID-19. We will accelerate our R&D activities to develop vaccines and therapeutics that are our duties".
Company
Listed ovarian anticancer Zejula applies for new indications
by
Eo, Yun-Ho
Mar 23, 2020 06:28am
PARP inhibitor Zejula Anticancer treatment Zejula, listed for pharmaceutical reimbursement last year, is now preparing for expanded label. According to related industry on Mar. 23, Takeda Pharmaceuticals Korea has recently submitted an application to expand reimbursement on DNA repairing Poly ADP-ribose Polymerase (PARP) inhibitor Zejula (niraparib). The anticancer treatment is targeting two additional indications; monotherapy for the maintenance treatment of BRCA-negative patients with platinum-sensitive relapsed high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy; and monotherapy to treat relapsed ovarian cancer after receiving third or later-line chemotherapy. Zejula is the first PARP inhibitor, used regardless of BRCA, indicated as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed high grade serous epithelial ovarian (fallopian tube or primary peritoneal cancer), who are in response (complete or partial) to platinum-based chemotherapy in Korea last March. Although it was listed for reimbursement last December, the first reimbursement standard is limited to patients with BRCA mutation. However, in major clinical studies, Zejula has demonstrated outstanding improvement on median Progression-Free Survival (mPFS) against placebo. For the fourth-line treatment indication was based on mutlicenter, open-label QUADRA study in adult patients with ovarian cancer, who have received third or later-line treatment. During the clinical study, Zejula demonstrated clinical efficacy with an object response rate (ORR), a primary efficacy endpoint. The patient group with platinum-sensitive homologous repair deficiency (HRD) demonstrated ORR of 24 percent, where as BRCA-positive platinum-sensitive group, BRCA-positive platinum-resistant group and BRCA-positive platinum-refractory group recorded ORR of 39 percent, 29 percent and 19 percent, respectively. And median duration of response (mDOR), a secondary efficacy endpoint, of Zejula was 8.3 months for platinum-sensitive HRD patient group. The study concluded the treatment’s safety profile can be adequately managed with adjusted dosage. Zejula was listed for reimbursement at a price of 76,400 won. The Korean health authority evaluated the treatment is more cost-efficient than AstraZeneca’s Lynparza (olaparib). But because Lynparza was listed with risk sharing agreement (RSA) and pharmacoeconomic evaluation-exemption track, the identical expenditure cap RSA was applied on Zejula as well.
Company
Chong Kun Dang co-market Xofluza with Roche
by
Chon, Seung-Hyun
Mar 23, 2020 06:27am
Chong Kun Dang announced on the 19th that it recently signed a joint sales contract with Roche Korea for domestic distribution of the influenza treatment drug 'Xofluza'. Xofluza by RocheRoche Korea and Chong Kun Dang jointly handle marketing and sales of Xofluza, and Chong Kun Dang is responsible for distribution. Xofluza is a drug used to treat influenza virus A/B infection in adolescents and adults over 12 years of age. This product has attracted attention as a new antiviral drug with a new mechanism of action developed after about 20 years since Tamiflu. Unlike conventional oral influenza treatments, which had to be administered for 5 days, Xofluza improved medication convenience so that it could be treated with only one dose. After taking it, it is evaluated that the symptom relief rate is fast and the time to stop the influenza virus detection is shortened. Nic Horridge, President of Roche Korea, said, "Xofluza is an influenza treatment with a new mechanism of action that suppresses the replication of influenza viruses. It has the convenience of a single dose. In cooperation with Chong Kun Dang, who has expertise in sales and marketing, we will present solutions to treatment areas that the existing antiviral drugs have not met and contribute to the promotion of public health”. President Young-ju Kim of Chong Kun Dang said, “We have continued to cooperate with Roche Korea in 2012 by jointly selling Tamiflu for the treatment of influenza. It is expected that this agreement will further strengthen cooperation between the two companies and show synergy”.
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