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Policy
The expansion of MPOX vaccination
by
Lee, Jeong-Hwan
May 03, 2023 05:38am
17 million adult males aged 20 to 64, 170,000, about 1%, the high-risk group estimated As the number of MPOX cumulative confirmed cases in Korea increased to 49, concerns about community infection grew, and domestic quarantine authorities decided to expand the target of third-generation MPOX vaccine to 'high-risk subjects of infection', drawing attention. Currently, the quarantine authorities are implementing the MPOX 3rd generation vaccine by dividing it into 'pre-exposure vaccination' for medical staff and 'post-exposure vaccination' for contacts. The plan is to add people at high risk of infection among the general public. The high-risk target for infection is estimated to be 17 million adult male sexual minorities between the ages of 20 and 64, and the quarantine authorities plan to more actively recommend and publicize the third-generation vaccine for them. On the 2nd, the Korea Centers for Disease Control and Prevention (KCDC) responded to a written inquiry related to the MPOX epidemic in the community by In-soon Nam, a member of the Democratic Party of Korea. Rep. Nam In-soon closely inquired about the possibility of an outbreak in the MPOX community, the vaccination of medical staff, the current status of high-risk groups, and plans for siege vaccination. According to the Agency for Disease Control and Prevention, as of the 27th of last month, 109 people have been vaccinated, including medical staff in treatment beds to treat MPOX patients, and 165 people have received the first vaccination. The second dose of Jynneos, a third-generation MPOX vaccine, should be administered 28 days after the first dose. The Agency for Disease Control and Prevention announced through an official document the implementation of vaccination for those who wish to be pre-vaccinated with the Mpox 3rd generation vaccine in 17 cities and provinces to improve vaccination, such as treatment bed medical staff, diagnostic test laboratory personnel, and epidemiological investigators. The hospital for the confirmed patient was informed by phone to the hospital and actively encouraged vaccination in advance. Going further here, the Agency for Disease Control and Prevention plans to implement the 3rd generation vaccination administration. This is to prevent infection in the MPOX community in advance. Specifically, the target of third-generation vaccination before MPOX exposure is not limited to medical staff, but is expanded to 'high-risk subjects of infection'. The Agency for Disease Control and Prevention estimated that about 170,000 LGBT people are the high-risk group, based on UNAIDS, an AIDS task force under the United Nations, at about 1% of the 17 million adult male population aged 20 to 64 in Korea. MPOX 3rd generation vaccine The Agency for Disease Control and Prevention said, “We are currently conducting pre-exposure vaccination for medical staff and post-exposure vaccination for contacts.” We will expand it to those at high risk of infection.” The Agency for Disease Control and Prevention predicted that sporadic MPOX infections would continue for the time being, but diagnosed that it was not at a level to worry about a pandemic at the level of Corona-19. Unlike respiratory infectious diseases such as COVID-19 and MERS, where droplets are the main route of infection, MPOX is mainly spread through the skin and sexual contact with symptomatic infected people, and it was presented on the basis that the risk of transmission is low on the general population other than the high-risk group. The Agency for Disease Control and Prevention said, "Recently, MPOX patients have been steadily occurring in the region, and are not limited to a specific region and are distributed across the country, so sporadic cases in the community will continue." The prevailing opinion is that it is not at the level of concern about the same pandemic.” The Agency for Disease Control and Prevention added, “MPOX, which is transmitted through skin and sexual contact, has a relatively low risk of transmission in the general population of Korea, not in the high-risk group.” Meanwhile, on August 11 last year, the Korean government introduced 10,000 doses for 5,000 Jynneos, the third-generation Mpox vaccine produced by Bavarian Nordic A/S, a foreign pharmaceutical company. The third-generation smallpox vaccine, Jynneos, has been approved by the FDA and EMA for being effective against both human and monkeypox.
Company
Boryung fails 3 of 5 patent challenges
by
Kim, Jin-Gu
May 03, 2023 05:38am
Boryung's omnidirectional patent challenge strategy on orignial anticancer drugs has been making slow progress. Since the end of 2021, Boryung filed patent challenges on 5 anticancer drugs, and lost or voluntarily withdrew 3 of those claims. Despite the strong drive it has been making for its anticancer drug business with plans to launch generics earlier by avoiding or invalidating patents, industry analysis is that the company would inevitably have to change its plans as it failed to cross the threshold of the first trial for several of its challenges already. ◆ Boryung fails first trial for Cabometyx but succeeds in deleting the original company’s patent paragraphs #iAccoridng to industry sources on the 13th, the Korea Property Trial and Appeals Board decided to dismiss the claims Boryung filed to invalidate the substance patent of Ipsen’s liver cancer treatment ‘Cabometyx (cabozantinib).’ Although it was Boryung’s loss on the surface, the analysis is that this is not the case in reality. This is because Ipsen, the original company, voluntarily deleted all of the paragraphs that were subject to the IPTAB’s review. Boryung initially sought to invalidate Cabometyx’s formulation patent paragraphs 1 to 25. Amid the ongoing dispute, Ipsen corrected the patent. Among paragraphs 1 to 27 in its patent, Ipsen voluntarily deleted paragraphs 1 to 25, which Boryung claimed were invalid. Due to the deletion, the subject to rule upon disappeared and the related disputes came to an end. Externally, the trial ended with IPTAB dismissing Boryung's request for trial as the subject itself to claim invalidity has disappeared and the company’s request did not meet the formal requirements. Industry analysis is that although Boryung lost on the surface, it succeeded in removing the risk factor for patent infringement. This means that even if a generic is released before the patent expires in February 2032, Boryung will not be infringing on the original drug’s patent. However, from Boryung's point of view, it is regrettable as the company cannot receive the generic exclusivity rights by winning the patent trial. To make up for this, Boryung is known to be considering requesting an additional trial to challenge Cabometyx’s two remaining patents. The remaining two crystalline patents expire in January and April 2030, respectively. If the company succeeds in invalidating or avoiding either patent, it will obtain one of the requirements for generic exclusivity. ◆Boryung loses first patent trial over Ibrance and appeals... voluntarily withdraws claims for Tasigna Since 2021, Boryung has filed patent trials for five anticancer drugs including Cabometyx. The other 4 include Eisai's liver cancer treatment 'Lenvima (lenvatinib)', BMS' acute lymphocytic leukemia treatment 'Sprycel (dasatinib)', Novartis' leukemia treatment 'Tasigna (nilotinib)', and Pfizer's breast cancer treatment 'Ibrance (palbociclib).’ Among the trials, the company failed the first trial after challenging Ibrance's crystalline patent. Boryung originally planned to release the generic early after avoiding Ibrance's crystalline patent, which expires in February 2034, but the plan was put to a stop with the failed trial. This is why Boryung appealed the decision of the first trial and dragged the case on to receive a second trial. The patent challenge to Tasigna ended with Boryung's voluntary withdrawal of its claims. In April last year, Boryung requested an omnidirectional trial on Tasigna’s four patents. However, in March, Boryeong voluntarily withdrew its trial. The pharmaceutical industry pointed to the company’s discontinuation of Tasigna’s generic drug development as the cause. On the other hand, the company won the challenge for the patent for the crystalline form of Sprycel. In June last year, Boryung ruled in favor of its trial to confirm the passive scope of rights for the patent. With the ruling, Boryung became one step closer to the early release of its Sprycel generic. In addition, the company had challenged Lenvima's patent but has not received results. As a result, the company has failed 3 of 5 the patent challenges it had filed against original anticancer drugs.
Company
‘Korea’s low reimb of orphan drugs needs to be improved’
by
Eo, Yun-Ho
May 03, 2023 05:38am
Study results have shown that Korea has low access to rare disease treatments. The Korean Research-based Pharmaceutical Industry Association (KRPIA) recently announced study results that stress Korea’s need to improve its reimbursement system in consideration of the characteristics held by rare diseases and rare disease treatments based on the ‘Study on the current status of access to rare disease treatments in Korea and measures to strengthen their coverage'. The results were derived from the research Professor Jong-Hyuk Lee from Chung-Ang University’s College of Pharmacy conducted as a principal investigator last year on the present status of access to rare disease treatments in Korea and measures to strengthen their coverage. The research analyzed the drugs in terms of usability –designation and marketing authorization of orphan drugs, and accessibility – reimbursement listing and medical expense support. The study pointed out how Korea defines orphan drugs and rare disease drugs separately and gives them different statuses and benefits, and that this disparity leads to the irrational result of drugs that are already approved as orphan drugs being unable to benefit from the system during the reimbursement evaluation process. In Korea, the reimbursement rate for orphan drugs (136) approved during the last decade (2012-2021) was 52.9%. When compared with similar research results overseas, this is a considerably lower level than that in Germany (93%) or France (81.1%). Also, it was noted that the average time required for orphan drugs or anticancer drugs to receive approval in Korea was 27.4 months, compared to 19.5 months in France and 18.6 months in Italy. Also, by analyzing the reimbursement rates of 136 orphan drugs approved in Korea according to special calculation exemption classification status, the study found that rare disease treatments(51.1%) and items ineligible for the special calculation exception (33.3%) showed lower reimbursement rates than anticancer drugs (57.6%). In other words, although the special calculation exemption system reduces the patient's burden for orphan drugs of rare diseases that are designated for special calculations, the system rather acts as an obstacle for diseases that are not subject to the special calculation exemption system that seeks to receive reimbursement. Korea's expenditures on orphan drugs is also 3.6%, which is lower than the OECD median of 6.8%, which is at the lower end among OECD countries. This shows the need for Korea to spend more on orphan drugs.
Policy
Pemazyre received domestic product approval
by
Lee, Hye-Kyung
May 02, 2023 03:40pm
Handok's locally advanced or metastatic cholangiocarcinoma treatment Pemazyre received domestic product approval on the 25th. The Ministry of Food and Drug Safety (Minister Oh Yoo-kyung) announced that it had approved three doses (4.5mg, 9mg, 13.5mg) of Pemazyre, an orphan drug. Pemazyre is an oral FGFR inhibitor that inhibits the proliferation of cancer cells caused by the fusion or rearrangement of fibroblast growth factor receptor 2 (FGFR2), which is involved in cell growth and differentiation. It is expected to provide a new treatment opportunity for adult patients with locally advanced or metastatic cholangiocarcinoma with FGFR2 fusion or rearrangement who have received one or more systemic treatments. Pemazyre is approved in the United States, Europe, and Japan for the treatment of adult patients diagnosed with locally advanced or metastatic cholangiocarcinoma with a fusion or rearrangement of the FGFR2 gene who have received at least one prior systemic therapy. In Korea, after being designated as an orphan drug in November 2021, it has been designated as a treatment for life-threatening or serious diseases since December. Previously, the US FDA designated Pemazyre as a breakthrough therapy for the treatment of previously treated patients with advanced, metastatic, or unresectable FGFR2 translocation cholangiocarcinoma, and designated it as an orphan drug, conducting an expedited review through a priority review program. Cholangiocarcinoma is a rare type of cancer and is classified according to its anatomical origin as iCCA and extrahepatic cholangiocarcinoma arising from the bile duct outside the liver. Cholangiocarcinoma is often diagnosed at an advanced or advanced stage with a poor prognosis. FGFR2 fusions or rearrangements are found in 10-16% of patients with intrahepatic cholangiocarcinoma. FGFRs play important roles in the proliferation, survival, migration, and angiogenesis of tumor cells. FGFR fusion, rearrangement, translocation, and gene amplification activities are closely related to the development of various cancers. Pemazyre is an oral FGFR inhibitor and is the first and only treatment approved by the FDA for this indication.
Company
Boryung signed a contract to establish a joint venture with
by
Kim, Jin-Gu
May 02, 2023 05:36am
Boryung announced on the 26th that it signed a contract to establish a joint venture (JV) with Axiom Space of the United States on the 25th (local time) to jointly promote the space business. Boryung CEO Kim Jeong-kyun, who visited the United States on an economic mission to the United States, signed a JV establishment contract with Axiom Space Chairman Kam Ghaffarian to jointly promote space projects in low-earth orbit. Axiom Space is an American company specializing in the space industry. Axiom is developing technology to carry out more missions in outer space more safely, including developing next-generation spacesuits that astronauts will wear on the moon in NASA's third Artemis mission. Boryung made a strategic investment of $60 million in Axiom Space last year. Then, in order to efficiently promote the project, detailed discussions related to the JV began in March. The JV will be established in Korea and plans to complete the establishment process within the first half of this year. Boryung and Axiom Space jointly invest at a ratio of 51:49, respectively. Based on Axiom Station, which will replace ISS, all business areas using Axiom's technology and infrastructure will be jointly promoted in Korea. Axiom Space will promote its business with exclusive rights in Korea for private and public space projects. It will be responsible for the astronaut business, joint manufacturing, construction, infrastructure-related businesses, including next-generation Korean modules, and all R&D and experimental activities at the space station. Boryung said, "This means that there is a channel that can utilize the low-earth orbit infrastructure, which has not been available in Korea," and expects that "this will serve as an opportunity to meet the numerous research and development demands arising from the microgravity environment in the future." The contract was signed during President Yoon Seok-yeol's state visit to the United States, with CEO Kim Jeong-gyun participating in an economic delegation. The Korean government is promoting the establishment of the Korea Aerospace Administration, a government control tower, along with the successful launch of the Nuri and Danuri with the goal of becoming one of the 7 significant powerhouses in space. am. “The establishment of this joint venture will serve as a foundation for both companies to share future visions for space development beyond a strategic investment relationship and design them together,” said CEO Jungkyun Kim. I will create an opportunity to contribute to development,” he said. CEO Kim was recently appointed a director of Axiom Space and joined the board of directors. Axiom announced that it had appointed three directors, including CEO Kim Jung-kyun, former CIA chief intelligence officer Jeanne Tisinger, and former US space operations commander John W. "Jay" Raymond. CEO Kim plans to participate in the decision-making process for the growth and business planning of Axiom Space as a member of the board of directors along with the best experts leading the US government and space industry, which is the 'Care In Space' project promoted by Boryeong. It is expected to be a great asset in accelerating the promotion and growth of
Company
Eylea Prefilled Syringe can be prescribed at GHs in KOR
by
Eo, Yun-Ho
May 02, 2023 05:36am
The pre-filled syringe formulation of Eylea can now be prescribed at general hospitals in Korea. According to industry sources, Bayer Korea's Wet Age-Related Macular Degeneration (wAMD) treatment 'Eylea Pre-filled Syringe,’ which was released with insurance reimbursement in October last year, has passed the drug committee reviews of tertiary hospitals in Korea, including the Seoul National University Hospital and Asan Medical Center. As a prefilled injection formulation, Eylea Pre-filled Syringes reduce preparation time for drug administration by allowing injection of a more accurate single dose than the existing Eylea vial formulations. The formulation offers easier administration with a 1mL glass syringe and a larger barrel and plunger button. Also, the luer-lock adaptor section that prevents the syringe and needle is transparent, allowing the user to check the needle attachment status. The Eylea Prefilled Syringe formulation is approved and reimbursed for all indications that are approved for the vial formulation. The company explained that Eylea’s sales have grown faster in European countries after the release of the pre-filled syringe formulations. In this sense, the company believes that the introduction of the Eylea Prefilled Syringe will serve as an opportunity to further solidify its position in the domestic anti-VEGF market. According to IQVIA, the domestic macular degeneration treatment market recorded KRW 126.3 billion last year, which is a 14% YoY increase from KRW 111.1 billion raised in the previous year. Eylea had broken its own annual sales record again with sales of KRW 80.4 billion last year. This is a 14% increase from the KRW 70.5 billion raise in Eylea set another record last year with annual sales of 80.4 billion won. This is a 14% increase from 70.5 billion won it had raised in 2021.
Company
Exkivity, an exon 20-targeted anti-cancer drug, can be presc
by
Eo, Yun-Ho
May 02, 2023 05:35am
Exkivity, an anticancer drug targeting EGFR exon 20 insertion mutations, can be prescribed at general hospitals. According to related industries, Exkivity, a treatment for non-small cell lung cancer with an EGFR exon 20 insertion mutation of Takeda Pharmaceutical Korea, passed the Drug Committees of the National Cancer Center, Seoul National University Hospital, and Samsung Seoul Hospital. As the insurance benefit registration process is currently in progress, it seems to focus on creating a prescription environment. Exkivity targets the same biomarker as Janssen Korea's Rybrevant, but with the difference that it is an oral drug. EGFR Exon 20 insertion mutation is a new biomarker that has recently attracted attention in the field of non-small cell lung cancer. Currently, available anticancer drugs are suitable for Exon19 deletion or Exon21 L858R substitution mutation, which are commonly found in EGFR mutations but are still in a blind spot for EGFR Exon20. Meanwhile, Rybrevant proved its efficacy through a phase 1/2 study conducted on 114 non-small cell lung cancer patients with an EGFR exon 20 insertion mutation who had previously received platinum-based chemotherapy. Clinical results, in the patient group who took Rybrevant 160 mg, the ORR evaluated by IRC was 28% and the mDOR was 17.5 months. In particular, the median reaction time after administration of Rybrevant was 1.9 months, confirming that the drug's effect appears quickly from the beginning of treatment. mPFS was 7.3 months and mOS was 24.0 months. The safety profile was also found to be favorable. The most common adverse reactions were diarrhea, rash, and fatigue, which can be managed by adjusting the dose.
Company
Gilead’s HCV drug occupies 19% of HCV market in 5 mths
by
Kim, Jin-Gu
May 02, 2023 05:35am
Gilead Science’s new hepatitis C treatment has made a successful soft landing in the market and derived good initial results. Epclusa and Vosevi, which were released in November last year, increased their market share to 19% in the oral hepatitis C treatment market in Q1 this year. On the other hand, the market share of Abbvie’s Mavyret, which previously dominated the market, fell from 81% in Q1 2022 to 74% in Q1 this year. ◆ The first new Gilead HCV drugs to be released in 8 years expand market share to 19% On the 2nd, according to the market research institution UBIST, the outpatient prescription sales of Gilead’s Epclusa reached KRW 1.1 billion in Q1 this year. During the same period, Vosevi’s sales recorded a prescription amount of KRW 500 million. The two drugs have occupied 19% of the total HCV market. Considering that it has been 5 months since its release, their performance is considered to be fair. Both products are HCV treatments released by Gilead in November last year. The company sought to recreate the glory it had enjoyed with Harvoni and Sovaldi with Epclusa and Vosevi. Gilead’s Harvoni and Sovaldi had once dominated the HCV treatment market. The drugs quickly replaced existing drugs with their release and recorded over KRW 100 billion in combined prescriptions in 2017. Its share soared to 77%. However, the situation changed with the introduction of the pan-genotypic treatment ‘Mavyret.’ can be used for patients with hepatitis C virus types 1 to 6, while Harvoni cannot be used for types 3 and Sovaldi cannot be used for types 5 and 6. The long treatment period of 12 weeks, compared to 8 weeks for Mavyret, also worked as a weakness for Harvoni and Sovaldi. Since then, Harvoni and Sovaldi's market share, which had reached 77% in 2017, fell sharply to 21% the following year. Last year, their share fell even further to 17%. Sovaldi’s sales fell to the extent that it faced the risk of revoking its marketing authorization during reevaluation review in 2021. ◆ Mavyret’s stronghold over the market falters after the introduction of Epclusa and Vosevi On the other hand, Mavyret quickly expanded its market share. In its first year of release, its shares soared from 12% in 2018 to 71% in 2019. Its share further increased to 85% last year, virtually dominating the HCV treatment market. In this situation, Gilead released a new hepatitis C treatment for the first time in eight years, heralding the return of the former market leader. In particular, Gilead set a lower price tag than Mavyret, expressing its will to retake the lead in the HCV market. Epclusa is priced at KRW 117,030 per tablet, and Vosevi KRW 120,836 per tablet. In terms of total treatment cost, Epclusa costs KRW 9,830,520 and Vosevi 10,150,224. This is cheaper than the KRW 10,922,352 it costs with Mavyret. The industry expects that although the treatment period of Epclusa and Vosevi is still longer than that of Mavyret by 12 weeks, their lower price and convenience in intake will further drive their occupation of Korea’s HCV treatment market. Epclusa is a pan-genotypic treatment like Mavyret. The treatment period is 12 weeks, which is about a month longer than that of Mavyret, but its administration of 1 tablet a day is simpler than that of Mavyret’s 3 tablets a day. In fact, Mavyret’s sales have been faltering since the introduction of Epklusa and Vosevi. Mavyret recorded prescription sales of KRW 6.4 billion in Q1, which is a 26% decrease from the KRW 8.6 billion it had raised in Q1 last year. Its market share has also fallen 7%p from 81% to 74%. ◆Made a successful soft landing, but the reduction in overall market size still remains a concern However, the contracting HCV treatment market remains a concern for the comapny's new treatment release. In fact, the size of the oral HCV treatment market has steadily decreased from KRW 135.3 billion in 2017 to KRW 73.7 billion in 2018, then to KRW 65.1 billion in 2019, and KRW 47.4 billion in 2020, KRW 35.1 billion in 2021, then to KRW 34.2 billion in 2022. Compared to 2017, when the market had expanded to its maximum, the market had shrunk to a quarter in 5 years. The industry pointed to the characteristics held by the HCV treatments as a cause of the market contraction. Before the introduction of direct-acting antivirals (DAAs) like Mavyret, HCV had been a very critical condition. However, the treatment effect of HCV drugs had increased dramatically with the introduction of BMS’s Daklinza and Sunvepra. With Gilead Sciences' Sovaldi and Harvoni, MSD’s Zepatier, and Abbvie’s Mavyret that followed, the treatment effect had further increased. With the treatment effect high enough to be close to a complete cure, the market size quickly contracted with the number of patients being prescribed the drug increasing within the finite number of patients in the market.
Company
SK Bioscience, Investing 2.4 trillion won over 5 years
by
Kim, Jin-Gu
Apr 30, 2023 09:46am
SK Bioscience has decided to invest 2.4 trillion won over the next five years. SK Bioscience announced on the 27th at 2:00 pm that it would announce its mid-to-long-term growth strategy to stock analysts and institutional investors. According to the disclosure, SK bioscience will spend 2.4 trillion won over the five years from this year to 2027 to ▲secure overseas production bases, ▲expand sales of SKYBAX, a vaccine developed in-house, ▲do CDMO business, and ▲premium vaccine business. are going to invest First of all, it secures a global production base that meets the environment and needs of each country around the world and creates various profit models to advance its assets. It plans to increase sales of SKYBAX, a self-developed vaccine project, to 220 billion won by 2024. Prior to this, the target for this year was set at 110 billion won. At the same time, the CDMO business is also in full swing. The plan is to expand the existing vaccine CDMO targeting global big pharma and promote a new bio CDMO centered on CGT. It is also accelerating its premium vaccine business. The phase 3 clinical plan for SKYBAX, a next-generation pneumococcal vaccine, will be finalized within this year, and HPV-10, a human papillomavirus (HPV) preventive vaccine, will be released in 2027. SK Bioscience expects the new HPV vaccine to generate cumulative sales of more than 2.5 trillion won over the three years after its release. It plans to launch a recombinant shingles vaccine in 2027, and to raise cumulative sales of more than 600 billion won over the next three years. SK Bioscience's sales, which were 929 billion won in 2021, decreased by 51% to 456.7 billion won last year. Operating profit fell 76% from 474.2 billion won to 115 billion won over the same period. SK Bioscience saw a surge in sales and operating profit in 2021 while consigning production of the Novavax vaccine. Sales, which stopped at 225.6 billion won in 2020, increased more than 4 times in a year, and operating profit also increased more than 12 times from 37.7 billion won. However, due to a decrease in the global corona vaccination rate, the consignment production of Novavax vaccine decreased, and as the production of existing products was stopped due to Novavax's vaccine stock change, both sales and operating profit of SK Bioscience decreased significantly.
Company
Hanmi, sales and operating profits highest in 8 years
by
Chon, Seung-Hyun
Apr 28, 2023 05:49am
Hanmi Pharmaceutical showed improved performance in the first quarter. Thanks to the high growth of new combination drugs such as Rosuzet and Amosartan family, both sales and operating profit recorded the highest level in eight years. Hanmi Pharmaceutical announced on the 26th that its operating profit in the first quarter was 60.5 billion won, up 47.9% from the same period last year. Sales were 361.7 billion won, up 12.6% from the previous year, and net profit was 49.6 billion won, up 98.1%. Both sales and operating profit are the highest since the fourth quarter of 2015. 2015 was a time when Hanmi Pharm recorded record-breaking performance by successively signing contracts for the export of super-large new drug technologies with Lilly, Boehringer Ingelheim, Janssen, and Sanofi. At this time, Hanmi Pharm reflected part of the down payment received from the technology transfer contract in its performance, and Hanmi Pharm posted sales of 589.9 billion won and an operating profit of 171.5 billion won in the fourth quarter of 2015 alone. The combination of new drugs developed by Hanmi Pharm with its research and development (R&D) capabilities led to an upward trend in performance. According to UBIST, a drug research institute, Hanmi Pharm raised the highest outpatient prescription amount of 219 billion won in the first quarter, taking the lead among domestic and foreign pharmaceutical companies. It rose 7.0% from the previous year, predicting the lead for six consecutive years. Hanmi Pharmaceutical ranked first in prescription performance for the first time in 2018 and then ranked first for five consecutive years until last year. Rosuzet, a combination drug for hyperlipidemia, recorded 41.5 billion won in prescriptions in the first quarter, up 13.1% from the previous year. Among all pharmaceuticals, it ranked second after Lipitor. Rosuzet, launched at the end of 2015, is a hyperlipidemia complex consisting of two ingredients, Rosuvastatin and Ezetimibe. Rosuzet is experiencing rapid growth thanks to market dominance and the popularity of its statin/ezetimibe complex. Rosuzet exceeded 100 billion won in prescriptions for three consecutive years from 2020. Rosuzet has been recording more than 10 billion won in prescriptions for 25 consecutive months from March 2021. Domestic pharmaceutical companies are entering the statin/ezetimibe market in droves and competing overheated, but Rosuzet has continued to grow rapidly based on its accumulated reliability. The Amosartan family also showed off their health. Hanmi Pharmaceutical is selling Amosartan Plus, Amosartan Q, and Amosartan X-Q, along with Amosartan, a combination drug that combines amlodipine and losartan ingredients. Amosartan Plus is a combination of three drugs: amlodipine, losartan, and chlorthalidone. Amosartan Q is a combination drug in which rosuvastatin, a hyperlipidemia treatment, is added to Amosartan. Amosartan XQ, released last year, is a product that combines amosartan with rosuvastatin and ezetimibe. Amosartan prescriptions in the first quarter were 22.1 billion won, up 3.6% from the previous year. Amosartan Plus posted 7.6 billion won, up 6.5% from the previous year, and Amosartan XQ recorded 2.3 billion won, more than doubling from the first quarter of last year. Beijing Hanmi Pharm, a local subsidiary in China, recorded sales of 111 billion won in the first quarter, up 17.% from the previous year, surpassing 100 billion won in sales in the first quarter. Operating profit and net profit were 30.8 billion won and 27.9 billion won, up more than 20% from the previous year, respectively. Compared to the same period last year, Beijing Hanmi Pharmaceutical’s main product, ‘Mommy I’, a children’s stomach medicine, grew by 31.6%, while ‘LiTong’, a laxative, and ‘Ambroxol HCl solution for inhalation’, a cough medicine, grew by 40% and 174.8%, respectively.
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