[ϸ= ] ࡤ̿ ̱ õ ̾鼭 üϴ ʵ ð ִ. ۷ι ž ŸӶ ª鼭 ž ġ ǰϰ ȴ.
ǥġ Ȱ ǥ̴. ְ̾ KRAS ǥ 忡 ž ñ ϸ鼭 Ĺڴ Ҹ ƴ. ̶Ƽ ϰ KRAS ǥ ϰ ־ 㰡 '۽Ʈ ' ڸ ִ ٶ . ӻ 㰡 3 ä Ǵ ӵ '縶ũ' ̸鼭 ̶Ƽ 縶ũ ȭ δ ־ ߴ. 㰡 6 ʾ. 縶ũ ϸ鼭 ̶Ƽ 'ƴٱ' 켱 ɻ簡 ƴ Ϲ ɻ Ʈ ƴ. 켱 ɻ 3 㰡 縶ũ ƴٱ 㰡 10 ٷ Ѵ.
Ǻ 㰡 縶ũ ̶Ƽ Ҹ Ȳ . 2 ƴٱ ȹ ̴. ֱ 縶ũ 3 ǥϸ ǥ Ⱓ(PFS) Ȯߴٰ ǥߴ. ٰŷ 縶ũ Ȯ Ǹ ̶Ƽ 8 3 ӻ ٷ ִ. ׳ 縶ũ 뺸 PFS ȿ üⰣ(OS) , ۿ ̶Ƽ ȭ ƴٱ ȿɰ ȴ.
ӻ ź ʸ 鵵 ް ִ. ѹ̾ǰ Ҽ ġ ž 'Ƽ' ֱ ǰǾ౹(FDA) ڹȸ Ȥ Ҵ. ڹⱸ ž ȿ ϴ ڹȸ(ODAC) ӽð, ۿ ŷϸ 㰡 ǥߴ.
HER2 ǥ üü(ADC) 8 FDAκ HER2 Ҽ 2 ġ Ҵ. 2 ġῡ ̴ 6~23% ݸ, 58% (ORR) ũ . ӱⰣ ߾Ӱ(mDOR) 8.7̾. Ǻ ߰ ӻ Ȯؾ 밨 ִ.
ݸ ORR 28%, mDOR 5.1 Ƽ ȿ ġ ʴٰ ڹ ߴ. Ƽ ۿ , 뷮 ȭ ϸ " Ƽ ε ǥġ ȿ ġ "̶ ߴ. Ƽ Ȯ ӻ 㰡 ɻ簡 ӻ 谡 ǵ ʾҰ, 7 28 ϵ ȯڵ ʹ ð ҿ ĩ ɰ ȯڸ Ⱓ ų ִٰ ߴ.
ž ӻ ϴ ǥġᰡ ٲ 賭 ȴ. 1 ǥġ ó ػ 鿪 ƼƮ ǥ ƹٽƾ ƴ. ֱ ǥ 1 ġ ӻ ǥؿ̾ ػٳ ̴. ƼƮ+ƹٽƾ Ȥ ؾ ʴĴ ǰߵ ִ.
ӻ ߾ 忡 ̶ ̴.
ȿ ϸ 㰡 ް, ż ǥؿ ӿ 츮 ϰ ϰ Ǵؾ ʿ䰡 ִ. ܼ ӻ Ȥ ж ̺й ڼ ֱ ǥؿ ִ, ġ 並 ä ȭ Ʈ ִ, ŸӶκ ӵ ʾ ĩ ̰ ϰ Ǵ ġ Ѵ. ܿ ž ο ۷ι Ϸ ࡤ̿ ϰ ʸ ֱ ٶ.
(same@dailypharm.com)